This book provides a comprehensive and thorough reference on the basics and practices of clinical trials, arguably the most important steps in proving a drug effective and safe for public use. With contributions from a range of international authors, the book takes the reader through each trial phase, technique, and issue. Chapters include interdisciplinary topics that have to be coordinated for a successful clinical trial: data management (and adverse event reporting systems), biostatistics, pharmacology, toxicology, modeling and simulation, regulatory monitoring, ethics, and particular issues for given disease areas (ie, cardiology, oncology, neuroscience, etc.).